Consortium for Economic Research on AD/ADRD Prevention, Treatment, and Care (R01 Clinical Trial Optional) | RFA AG 24 031

Opportunity Information: Apply for RFA AG 24 031

The National Institutes of Health (NIH) is soliciting applications under funding opportunity RFA-AG-24-031 for R01 research projects focused on the economics of Alzheimer's disease (AD) and AD-related dementias (ADRD). The goal is to strengthen evidence on how economic and health system forces shape the prevention, treatment, and care of people living with dementia (PLWD), including the experiences and outcomes of their caregivers. Clinical trials are optional, meaning applicants may propose studies that include trials or rely on other rigorous designs such as observational analyses, quasi-experimental methods, policy evaluations, and implementation-focused economic research.

A central emphasis of the opportunity is understanding how treatment and care innovations are developed, adopted, and spread in real-world settings. This includes studying what helps or hinders the diffusion of new clinical practices, care coordination approaches, caregiver supports, technologies, or service delivery models. The NOFO also encourages research on payment and treatment models, such as how reimbursement rules, insurance design, value-based payment arrangements, and alternative care models influence provider behavior, care quality, utilization, and costs. Another major theme is access: applicants are encouraged to examine economic barriers and facilitators that affect whether PLWD and caregivers can obtain appropriate services across the care continuum, including diagnosis, treatment, long-term services and supports, and caregiver resources. In addition, the NOFO highlights work on economic factors that may influence disease progression, which can include the roles of socioeconomic status, financial strain, labor market impacts, and broader policy environments on health trajectories and care needs.

Projects funded through this NOFO will be part of a broader NIH-supported consortium and will be connected to the Consortium for Economic Research on AD/ADRD Prevention, Treatment and Care Coordination Center (RFA-AG-24-030). That linkage is meant to create collaboration across funded projects, reduce duplicated effort, and build shared infrastructure for dementia-related economic research. Investigators are expected to work with the Coordinating Center to share research resources and tools generated through their projects, both within the consortium and, where appropriate, for wider health research use. In practice, this often implies coordination on common measures, data harmonization, methods, dissemination strategies, and cross-project learning.

The opportunity is offered as a discretionary grant under the NIH R01 mechanism in the health funding activity area (CFDA 93.866). The listed award ceiling is $400,000. The original closing date provided is October 30, 2023, and the posting indicates NIH as the sponsoring agency. While the summary does not specify the number of awards, it frames the program as building a networked set of projects rather than isolated studies.

Eligibility is broad and includes many types of U.S.-based applicants: state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses; and other entities as permitted. The NOFO explicitly calls out additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. Foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible; however, foreign components (as defined in the NIH Grants Policy Statement) are allowed, which generally means discrete, well-justified parts of a project may be carried out abroad under a U.S. applicant organization when scientifically necessary.

Overall, this NOFO is aimed at producing policy-relevant, actionable economic evidence that can improve how dementia care and supports are financed, delivered, and accessed, while also building a coordinated research community that shares data resources, methods, and insights to accelerate progress in AD/ADRD prevention, treatment, and care.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Consortium for Economic Research on AD/ADRD Prevention, Treatment, and Care (R01 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
• This funding opportunity was created on 2023-08-28.
• Applicants must submit their applications by 2023-10-30. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $400,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA AG 24 031

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