Opportunity Information: Apply for RFA HG 25 005
The National Institutes of Health (NIH), through the National Human Genome Research Institute (NHGRI), is offering a discretionary grant opportunity titled "Enhancing Reuse of NHGRI Data Assets (R03 Clinical Trial Not Allowed)" under funding opportunity number RFA-HG-25-005 (CFDA/Assistance Listing 93.172). The main goal is to encourage and fund small, focused research projects that perform secondary analyses of existing NHGRI-supported datasets that are available through the AnVIL platform (Analysis, Visualization, and Informatics Lab-space). The intent is practical: help researchers reuse high-value genomic and related datasets without having to generate new data, and lower the entry barrier for teams that are new to AnVIL by offsetting the platform-related costs that can otherwise discourage exploratory or early-stage projects.
This opportunity is specifically aimed at increasing utilization of AnVIL for smaller-scale studies while also demonstrating the scientific value of NHGRI data assets when they are reused for new questions. By supporting additional analyses on top of already-collected datasets, NHGRI is looking to stimulate new discoveries, reveal fresh insights, and show how effective AnVIL can be as a shared cloud-based environment for collaborative genomic research. In other words, the program is designed to get more researchers working directly in the AnVIL ecosystem, producing publishable results and methodological progress from existing data, and making it easier for new users to participate without being blocked by compute or access-related costs.
The award mechanism is an NIH R03 (small research grant), and clinical trials are not allowed, meaning proposed work must not include prospective assignment of human participants to interventions to evaluate health-related outcomes. Projects should instead focus on secondary data analysis, reuse, reanalysis, integration, or related computational research activities that leverage AnVIL-hosted datasets. The award ceiling listed for this opportunity is $125,000, signaling that the scope should be tightly defined and achievable with modest resources, which is consistent with the R03’s purpose of supporting pilot work, feasibility studies, or other small projects that can quickly generate useful findings.
Eligibility is broad and includes many types of U.S. organizations and some non-U.S. entities. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized governments; public housing authorities/Indian housing authorities; nonprofit organizations with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other eligible organizations. The announcement also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); eligible federal agencies; faith-based or community-based organizations; Hispanic-serving institutions; historically Black colleges and universities (HBCUs); Indian/Native American tribal governments other than federally recognized; tribally controlled colleges and universities (TCCUs); regional organizations; U.S. territories or possessions; and non-domestic (non-U.S.) entities/foreign organizations, which broadens participation and encourages diverse institutional involvement in NHGRI data reuse.
Key administrative details provided include an original closing date of February 15, 2026, and a creation date for the opportunity record of November 18, 2024. The funding instrument type is a grant, and the activity category is health. While the summary does not list the expected number of awards, it clearly frames the program as a way to catalyze additional discovery from NHGRI datasets and to demonstrate AnVIL’s value as a platform by funding small, secondary-analysis projects that might otherwise not proceed due to cost barriers.Apply for RFA HG 25 005
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Enhancing Reuse of NHGRI Data Assets (R03 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172.
- This funding opportunity was created on 2024-11-18.
- Applicants must submit their applications by 2026-02-15. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $125,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this NIH grant opportunity?
The opportunity is titled "Enhancing Reuse of NHGRI Data Assets (R03 Clinical Trial Not Allowed)".
Which NIH institute is offering this funding?
This discretionary grant opportunity is offered by the National Institutes of Health (NIH) through the National Human Genome Research Institute (NHGRI).
What is the funding opportunity number?
The funding opportunity number is RFA-HG-25-005.
What is the Assistance Listing (CFDA) number for this opportunity?
The CFDA/Assistance Listing number provided is 93.172.
What is the main purpose of this funding opportunity?
The main goal is to encourage and fund small, focused research projects that conduct secondary analyses of existing NHGRI-supported datasets that are available through the AnVIL platform. The intent is to promote reuse of high-value datasets without generating new data, and to reduce platform-related cost barriers that can prevent exploratory or early-stage projects.
What types of projects does NHGRI want to support?
The opportunity is aimed at smaller-scale studies that reuse, reanalyze, integrate, or otherwise perform computational and analytical work on AnVIL-hosted NHGRI-supported datasets. The program emphasizes practical secondary analysis work that can demonstrate scientific value and encourage broader adoption of AnVIL.
Does this funding support generating new datasets?
The opportunity is focused on secondary analyses of existing NHGRI-supported datasets available through AnVIL. The description emphasizes reusing already-collected data rather than generating new data.
What platform must the datasets come from?
The opportunity targets secondary analyses of NHGRI-supported datasets that are available through AnVIL (Analysis, Visualization, and Informatics Lab-space).
Why is AnVIL central to this opportunity?
NHGRI is trying to increase utilization of AnVIL by funding projects that work directly within the AnVIL ecosystem. A major motivation described is to lower barriers for teams that are new to AnVIL by helping offset platform-related costs that might otherwise discourage early-stage or exploratory reuse projects.
What is the award mechanism (grant type)?
The award mechanism is an NIH R03 (Small Research Grant).
What does "R03" imply about the scope of work?
The R03 mechanism is described here as supporting small, tightly defined projects consistent with pilot work, feasibility studies, or other focused efforts designed to generate useful findings with modest resources.
Are clinical trials allowed under this opportunity?
No. This opportunity is labeled "Clinical Trial Not Allowed". Proposed work must not include the prospective assignment of human participants to interventions to evaluate health-related outcomes.
If clinical trials are not allowed, what kinds of research activities fit?
The description indicates projects should focus on secondary data analysis, including reuse, reanalysis, integration, and related computational research activities that leverage datasets hosted on AnVIL.
What is the maximum award amount (ceiling) mentioned?
The award ceiling listed is $125,000.
Is the purpose partly to help with cloud or platform-related costs?
Yes. A stated intent is to lower the entry barrier for teams new to AnVIL by offsetting platform-related costs that can discourage exploratory or early-stage projects.
What outcomes is NHGRI hoping to see from funded projects?
The opportunity is designed to stimulate new discoveries and insights from existing datasets, demonstrate the scientific value of NHGRI data assets when reused for new questions, and show how effective AnVIL can be as a shared, cloud-based environment for collaborative genomic research.
What is the funding instrument type?
The funding instrument type is a grant.
What is the activity category for this opportunity?
The activity category is listed as health.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. organizations and some non-U.S. entities. Eligible applicants listed include:
- State, county, city, or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Tribal organizations other than federally recognized governments
- Public housing authorities/Indian housing authorities
- Nonprofit organizations with and without 501(c)(3) status (other than institutions of higher education)
- For-profit organizations other than small businesses
- Small businesses
- Other eligible organizations
Are minority-serving institutions and other special categories mentioned as eligible?
Yes. The announcement highlights additional eligible applicant categories, including:
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
- Hispanic-serving institutions
- Historically Black colleges and universities (HBCUs)
- Tribally controlled colleges and universities (TCCUs)
- Faith-based or community-based organizations
- Regional organizations
- U.S. territories or possessions
- Eligible federal agencies
Are non-U.S. (foreign) organizations eligible?
Yes. The opportunity explicitly includes non-domestic (non-U.S.) entities/foreign organizations among eligible applicants.
What is the original closing date for this opportunity?
The original closing date provided is February 15, 2026.
What is the opportunity record creation date?
The creation date provided for the opportunity record is November 18, 2024.
Is the expected number of awards stated?
No. The summary provided does not list an expected number of awards.
What is the practical benefit of doing the work as secondary analysis rather than collecting new data?
As described, the program is intended to produce new discoveries and insights by building on existing, high-value NHGRI datasets, while avoiding the cost and time of generating new datasets. It also aims to make it easier for new users to work in AnVIL without being blocked by compute or access-related costs.
Is this opportunity described as discretionary?
Yes. The opportunity is described as a discretionary grant opportunity.
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