Opportunity Information: Apply for PAR 19 234
The National Institutes of Health (NIH) announced a limited-competition funding opportunity titled "Limited Competition: Additional Sequencing for the Alzheimer's Disease Sequencing Project (U01 Clinical Trial Not Allowed)" under Funding Opportunity Number PAR-19-234. This is a discretionary health research award made through a cooperative agreement (U01), meaning the NIH is expected to have substantial scientific and programmatic involvement during the project period rather than functioning only as a passive funder. The announcement is focused on expanding and supporting the Alzheimer's Disease Sequencing Project (ADSP) Follow-Up Study by generating additional genetics and genomics data that can be used by the broader research community to better understand the genetic architecture of Alzheimer's disease.
The work supported by this FOA centers on the practical and technical activities required to produce high-quality sequencing and association data at scale. Specifically, applicants are invited to propose efforts related to sample acquisition, genome-wide association studies (GWAS), whole genome sequencing (WGS), and the downstream steps needed to make those data usable and reliable, including quality control checks, variant calling, and broader data processing ("data calling"). In plain terms, the opportunity is aimed at groups that can help obtain appropriate samples and then carry out, standardize, and validate the laboratory and computational workflows that turn biological specimens into clean, well-annotated datasets suitable for Alzheimer’s genetics research. The "Clinical Trial Not Allowed" designation indicates that the proposed work must not include a clinical trial component as defined by NIH, keeping the scope centered on data generation and analysis rather than interventional human subjects research.
Eligibility is broad and includes many common applicant types across government, academia, nonprofits, and industry. Eligible domestic applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; and Native American tribal organizations other than federally recognized tribal governments. The FOA also allows nonprofit organizations (both with and without 501(c)(3) status, as long as they are not institutions of higher education), for-profit organizations (other than small businesses), and small businesses. In addition, the announcement explicitly highlights a range of other eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. Notably, non-U.S. entities (foreign organizations) are also listed as eligible, reflecting the reality that large-scale genomics efforts can involve international sequencing capacity, analytic expertise, or access to specific cohorts.
The FOA is associated with CFDA number 93.866 and was created on April 2, 2019. The original closing date shown is May 7, 2022. The public summary does not provide an award ceiling or expected number of awards, suggesting applicants would need to consult the full FOA text and related NIH guidance for budget limits, project period expectations, and program priorities. Overall, this opportunity is best understood as NIH support for the infrastructure and execution of additional Alzheimer’s sequencing and genetics work: acquiring or organizing samples, running GWAS and whole genome sequencing, and delivering rigorously quality-controlled variant datasets that strengthen the ADSP Follow-Up Study and accelerate downstream discovery.Apply for PAR 19 234
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: Additional Sequencing for the Alzheimer's Disease Sequencing Project (U01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2019-04-02.
- Applicants must submit their applications by 2022-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled "Limited Competition: Additional Sequencing for the Alzheimer's Disease Sequencing Project (U01 Clinical Trial Not Allowed)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PAR-19-234.
Which agency is offering this grant?
This funding opportunity is offered by the National Institutes of Health (NIH).
What type of award mechanism is being used?
The award mechanism is a cooperative agreement (U01). This is described as a discretionary health research award.
What does a U01 cooperative agreement mean for applicants and awardees?
A U01 cooperative agreement means NIH expects to have substantial scientific and programmatic involvement during the project period. In other words, NIH is not only providing funds; it is also expected to be actively involved in aspects of project oversight and coordination.
What is the overall purpose of this FOA?
The purpose is to expand and support the Alzheimer's Disease Sequencing Project (ADSP) Follow-Up Study by generating additional genetics and genomics data that can be used by the broader research community to better understand the genetic architecture of Alzheimer's disease.
How does this FOA relate to the Alzheimer's Disease Sequencing Project (ADSP)?
This FOA specifically supports additional sequencing and related genetics/genomics work that strengthens the ADSP Follow-Up Study through new data generation and processing.
What kinds of activities or work does NIH want to support under this announcement?
The FOA centers on practical and technical activities needed to produce high-quality sequencing and association data at scale, including sample acquisition, genome-wide association studies (GWAS), whole genome sequencing (WGS), and downstream steps that make the data usable and reliable.
Does the FOA support sample acquisition?
Yes. Applicants are invited to propose efforts related to sample acquisition as part of the workflow to generate additional Alzheimer’s genetics and genomics data.
Are GWAS activities within scope for this opportunity?
Yes. Genome-wide association studies (GWAS) are explicitly listed among the efforts applicants are invited to propose.
Is whole genome sequencing (WGS) included in the scope?
Yes. Whole genome sequencing (WGS) is explicitly included as a supported activity area.
What does "downstream steps" mean in the context of this FOA?
In this FOA, downstream steps refer to the processes needed to make generated data usable and reliable, including quality control checks, variant calling, and broader data processing (also described as "data calling").
What is meant by "quality control checks" in this FOA summary?
The summary indicates that NIH is looking for workflows that include quality control checks to ensure the sequencing and association outputs are high quality and reliable for research use.
What is variant calling, and is it expected under this FOA?
Variant calling is listed as one of the downstream steps supported by this FOA. Based on the summary, it is part of the processing needed to turn sequencing output into usable variant datasets.
What is "data calling" as described in the opportunity summary?
The summary uses "data calling" to refer broadly to downstream data processing steps (including variant calling and related processing) that help produce clean, well-annotated datasets.
What is the intended end product or deliverable of the work?
The intended output is high-quality genetics and genomics datasets, including rigorously quality-controlled variant datasets, suitable for Alzheimer’s genetics research and usable by the broader research community.
Is this funding opportunity intended for clinical trials?
No. The FOA is designated "Clinical Trial Not Allowed," which indicates the proposed work must not include a clinical trial component as defined by NIH.
If clinical trials are not allowed, what is the focus instead?
The focus is on data generation and analysis activities (such as sample acquisition, sequencing, GWAS, and data processing/quality control) rather than interventional human subjects research.
Is eligibility limited or broad?
Eligibility is broad and includes many applicant types across government, academia, nonprofits, and industry. The title indicates a limited-competition opportunity, but the public summary provided focuses on eligible organization types.
Which U.S. government entities are eligible to apply?
Eligible domestic applicants include state governments, county governments, city or township governments, special district governments, and independent school districts.
Are public institutions of higher education eligible?
Yes. Public and state-controlled institutions of higher education are listed as eligible.
Are private institutions of higher education eligible?
Yes. Private institutions of higher education are listed as eligible.
Are tribal governments or tribal organizations eligible?
Yes. Federally recognized Native American tribal governments are eligible, and Native American tribal organizations other than federally recognized tribal governments are also listed as eligible.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations are eligible both with and without 501(c)(3) status, as long as they are not institutions of higher education.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also listed as eligible.
Are small businesses eligible to apply?
Yes. Small businesses are explicitly included among eligible applicants.
Are non-U.S. (foreign) organizations eligible?
Yes. The announcement lists non-U.S. entities (foreign organizations) as eligible.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are listed among eligible applicant categories.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly highlighted among eligible applicant categories.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are included among the listed eligible applicant categories.
Are regional organizations eligible?
Yes. Regional organizations are listed as eligible.
Are minority-serving institutions mentioned as eligible?
Yes. The opportunity explicitly highlights several categories, including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are listed as eligible.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA number 93.866.
When was this FOA created?
The FOA was created on April 2, 2019.
What is the closing date listed in the summary?
The original closing date shown is May 7, 2022.
Does the public summary include an award ceiling or the expected number of awards?
No. The public summary does not provide an award ceiling or the expected number of awards.
Where would an applicant typically look for budget limits or project period expectations?
Based on the summary, applicants would need to consult the full FOA text and related NIH guidance for budget limits, project period expectations, and program priorities.
What makes this opportunity a good fit for sequencing or genomics groups?
The summary indicates the FOA is aimed at groups that can obtain appropriate samples and carry out, standardize, and validate laboratory and computational workflows that turn biological specimens into clean, well-annotated datasets for Alzheimer’s genetics research.
How are the generated data intended to be used?
The generated genetics and genomics data are intended to be used by the broader research community to improve understanding of the genetic architecture of Alzheimer's disease and to accelerate downstream discovery.
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| International Research Ethics Education and Curriculum Development Award (R25 Clinical Trial Not Allowed) Apply for PAR 19 244 Funding Number: PAR 19 244 Agency: National Institutes of Health Category: Health Funding Amount: $230,000 |
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| Research Projects to Improve the Predictive Value of Animal Models in Recapitulating Human Immunity to Influenza Infection and Vaccination (R01 Clinical Trial Not Allowed) Apply for PAR 19 248 Funding Number: PAR 19 248 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
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| MOMENTUM (Moving Integrated, Quality Maternal, Newborn, and Child Health Services, Voluntary Family Planning, and Reproductive Health Care [MNCH/FP/RH] to Scale) Apply for 7200AA19APS00002 Funding Number: 7200AA19APS00002 Agency: Agency for International Development Category: Health Funding Amount: $500,000,000 |
| NEI Research Grant for Vision-Related Secondary Data Analysis (R21 Clinical Trial Not Allowed) Apply for PAR 19 260 Funding Number: PAR 19 260 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
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