Opportunity Information: Apply for PAR 17 094
The Maximizing Investigators' Research Award (MIRA) (R35) is a National Institutes of Health (NIH) grant opportunity from the National Institute of General Medical Sciences (NIGMS) designed to support an investigator's overall research program rather than a single, tightly defined project. In this context, a "program of research" means the collection of related projects conducted in an investigator's laboratory that align with the NIGMS mission. The central idea is to provide more flexible, stable support so investigators can pursue cohesive lines of inquiry, adapt to new findings, and manage their labs more efficiently without having to constantly repackage work into multiple separate grant applications. Overall, the stated goal is to increase the efficiency and effectiveness of NIGMS funding by investing in investigators and their broader research directions.
This opportunity is a discretionary, health-focused grant mechanism (Funding Instrument: Grant; Activity Category: Health) under Funding Opportunity Number PAR 17 094, associated with CFDA number 93.859. The opportunity was created on 2016-12-21, and the original closing date listed for the competition was 2019-05-17. The listing does not provide an award ceiling or expected number of awards, which typically means applicants need to consult the full announcement and NIH policy details for budget expectations, award ranges, and how many awards might be made in a given cycle.
Eligibility is broad and includes many types of U.S.-based organizations and government entities. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofits both with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and other entities as allowed by NIH policy. The opportunity also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American Tribal Governments other than federally recognized entities, and U.S. territories or possessions.
Restrictions related to foreign participation are specific. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply as applicant organizations, and non-domestic components of U.S. organizations are not eligible to apply. However, "foreign components" are allowed as defined in the NIH Grants Policy Statement, meaning a U.S. applicant may include certain elements of the work that take place outside the United States if they meet NIH's definition and requirements for a foreign component (for example, specialized resources, unique populations, or collaborations abroad that are justified and appropriately documented).
In practical terms, MIRA is meant for investigators whose labs run multiple interrelated projects within NIGMS-relevant areas and who would benefit from a single award supporting that integrated program. Instead of funding a narrowly scoped aim set, this mechanism emphasizes supporting the overall direction and productivity of the investigator's research enterprise, with the broader intent of reducing administrative burden, improving continuity of support, and enabling more responsive and innovative science within NIGMS's mission space.Apply for PAR 17 094
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Maximizing Investigators' Research Award (R35)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859.
- This funding opportunity was created on 2016-12-21.
- Applicants must submit their applications by 2019-05-17. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Maximizing Investigators' Research Award (MIRA) (R35) - FAQs
What is the Maximizing Investigators' Research Award (MIRA) (R35)?
MIRA (R35) is an NIH grant opportunity from the National Institute of General Medical Sciences (NIGMS) that supports an investigator's overall research program rather than a single, tightly defined project.
Which NIH institute offers this MIRA opportunity?
This opportunity is offered by the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health (NIH).
What does MIRA mean by a "program of research"?
In this context, a "program of research" means the collection of related projects conducted in an investigator's laboratory that align with the NIGMS mission.
How is MIRA different from a traditional project-based grant?
Rather than focusing on a single, narrowly scoped set of aims, MIRA is designed to support the overall direction of an investigator's research enterprise, providing flexibility to adapt to new findings and pursue cohesive lines of inquiry within NIGMS-relevant areas.
What is the main purpose or goal of the MIRA mechanism?
The stated goal is to increase the efficiency and effectiveness of NIGMS funding by investing in investigators and their broader research directions, with more stable and flexible support.
What funding instrument and activity category does this opportunity use?
The listing identifies it as a discretionary, health-focused mechanism with Funding Instrument: Grant and Activity Category: Health.
What is the Funding Opportunity Number (FON) for this MIRA listing?
The Funding Opportunity Number provided is PAR 17 094.
What CFDA number is associated with this opportunity?
The listing associates this opportunity with CFDA 93.859.
When was this grant opportunity created?
The opportunity was created on 2016-12-21.
What was the original closing date listed for this competition?
The original closing date listed was 2019-05-17.
Does the listing provide an award ceiling or the expected number of awards?
No. The listing does not provide an award ceiling or an expected number of awards. Applicants typically need to consult the full announcement and NIH policy details for budget expectations, award ranges, and the number of awards that may be made.
Who is eligible to apply for this MIRA opportunity?
Eligibility is broad and includes many U.S.-based organizations and government entities, as allowed by NIH policy.
What types of government entities are eligible applicants?
Eligible applicants include state governments, county governments, city or township governments, and special district governments.
Are educational institutions eligible to apply?
Yes. Eligible applicants include independent school districts, public and state-controlled institutions of higher education, and private institutions of higher education.
Are tribal governments or tribal organizations eligible?
Yes. Eligible applicants include federally recognized Native American tribal governments and Native American tribal organizations other than federally recognized tribal governments. The listing also highlights Indian/Native American Tribal Governments other than federally recognized entities.
Are nonprofits eligible to apply?
Yes. Eligible applicants include nonprofits with 501(c)(3) status (other than institutions of higher education) and nonprofits without 501(c)(3) status (other than institutions of higher education).
Are for-profit organizations eligible to apply?
Yes. Eligible applicants include for-profit organizations other than small businesses, as well as small businesses.
Are housing authorities eligible applicants?
Yes. Public housing authorities and Indian housing authorities are listed as eligible applicants.
Are U.S. territories or possessions eligible?
Yes. The opportunity highlights U.S. territories or possessions as eligible applicant categories.
Are faith-based or community-based organizations eligible to apply?
Yes. The opportunity highlights faith-based or community-based organizations as additional eligible applicant categories.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The listing highlights eligibility for Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are eligible federal agencies allowed to apply?
Yes. The opportunity highlights eligible federal agencies as an eligible applicant category.
Are non-U.S. (foreign) institutions eligible to apply as applicant organizations?
No. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply as applicant organizations.
Can a non-domestic component of a U.S. organization apply directly?
No. Non-domestic components of U.S. organizations are not eligible to apply.
Are "foreign components" allowed under this opportunity?
Yes. Foreign components are allowed as defined in the NIH Grants Policy Statement, meaning a U.S. applicant may include certain elements of the work that take place outside the United States if they meet NIH's definition and requirements.
What is an example of when a foreign component might be included?
The listing notes examples such as using specialized resources, accessing unique populations, or establishing collaborations abroad, when justified and appropriately documented under NIH requirements.
What kind of investigator or lab is MIRA intended to support?
MIRA is meant for investigators whose labs run multiple interrelated projects within NIGMS-relevant areas and who would benefit from a single award supporting that integrated program.
How does MIRA aim to reduce administrative burden?
By supporting an integrated research program under a single award, MIRA is intended to reduce the need to constantly repackage related work into multiple separate grant applications.
How does MIRA support innovation and adaptability in research?
The mechanism is designed to provide flexible and stable support so investigators can adapt to new findings and pursue cohesive lines of inquiry without being locked into a single tightly defined project structure.
What is the alignment requirement for the research supported by MIRA?
The supported program of research should align with the NIGMS mission, as described in the listing.
Where should applicants look for budget expectations or award size guidance?
Because the listing does not provide an award ceiling or expected number of awards, applicants typically need to consult the full announcement and NIH policy details for budget expectations and award ranges.
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| Strengthening the HIV Pre-Exposure Prophylaxis (PrEP) Care Continuum through Behavioral, Social, and Implementation Science (R21) Apply for PA 17 103 Funding Number: PA 17 103 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Strengthening the HIV Pre-Exposure Prophylaxis (PrEP) Care Continuum through Behavioral, Social, and Implementation Science (R01) Apply for PA 17 104 Funding Number: PA 17 104 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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| NK Cells to Induce Immunological Memory to Prevent HIV Infection (R01) Apply for PA 17 114 Funding Number: PA 17 114 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Development of Socially-Assistive Robots (SARs) to Engage Persons with Alzheimer's Disease (AD) and AD-Related Dementias (ADRD), and their Caregivers (R41/R42) Apply for PAR 17 107 Funding Number: PAR 17 107 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Development of Socially-Assistive Robots (SARs) to Engage Persons with Alzheimer's Disease (AD) and AD-Related Dementias (ADRD), and their Caregivers (R43/R44) Apply for PAR 17 108 Funding Number: PAR 17 108 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Targeted basic behavioral and social science and intervention development for HIV prevention and care (R01) Apply for PA 17 106 Funding Number: PA 17 106 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Targeted basic behavioral and social science and intervention development for HIV prevention and care (R21) Apply for PA 17 105 Funding Number: PA 17 105 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
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| Project Manager for Kenya PEPFAR Sites Analysis Apply for SBUR SOGAC 16 003 Funding Number: SBUR SOGAC 16 003 Agency: Office of the Secretary Category: Health Funding Amount: $3,100,000 |
| Expanding and Strengthening Family Planning Service Options in Uganda Apply for RFA 617 17 000002 Funding Number: RFA 617 17 000002 Agency: Uganda USAID-Kampala Category: Health Funding Amount: $35,000,000 |
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