Opportunity Information: Apply for CDC RFA GH19 1921
The grant opportunity titled Optimizing Performance by Improving Quality (OPIQ) focuses on strengthening HIV and HIV/TB program results in South Africa by using structured Quality Improvement (QI) approaches to raise the consistency and reliability of service delivery. It is part of the Presidents Emergency Plan for AIDS Relief (PEPFAR) and is designed to help both PEPFAR-funded implementing partners and the South African Government (SAG) health system, specifically national, provincial, and district Departments of Health. The central idea is that better performance on key HIV and TB indicators does not come only from adding more activities, but from tightening how existing services are delivered, monitored, and improved over time so that programs meet recognized standards and sustain gains toward epidemic control.
A major component of the work is hands-on technical assistance aimed at finding and closing performance gaps. This includes conducting initial and ongoing assessments to identify where HIV and TB prevention and treatment services are falling short, why those gaps exist, and what practical remedial plans can fix them. In practice, this can involve reviewing routine program data, tracing client flow through services, examining adherence to clinical guidelines, and working with local teams to address bottlenecks that reduce testing yield, delay treatment initiation, weaken retention, or undermine viral load monitoring and suppression. The expectation is not a one-time assessment, but a continuous cycle of measurement, learning, and adjustment.
Another core purpose is to ensure that HIV/TB service delivery aligns with both global and national quality standards. The opportunity emphasizes using QI methods alongside quality assurance (QA) assessments to verify that programs are not only expanding coverage, but delivering care correctly and safely. QI generally refers to systematic problem-solving approaches that help teams test changes, measure results, and scale what works, while QA is often focused on checking compliance with defined standards. Together, these approaches help identify whether facilities and district programs are delivering services as intended and whether the resulting care is producing the expected outcomes for patients.
The announcement also highlights a strong data use and analytics focus. Awardees are expected to help with the operationalization and interpretation of complex analyses, including creating data visualizations and presentations that make performance trends and quality issues easier to understand and act on. This is important in large public health programs where decision-makers need clear, timely insights to prioritize actions across districts and technical areas. The intent is to move beyond simply reporting numbers and instead support meaningful analysis that explains what is happening, where it is happening, and what should be done next.
Capacity building is another major pillar. The grant is meant to strengthen the ability of implementing partners and SAG health authorities at national, provincial, and district levels to independently deliver high-quality HIV/TB services. That can include mentoring and coaching of health teams, building skills in QI methodology, strengthening routine monitoring and supportive supervision, and improving how teams interpret data and run improvement projects. The long-term aim is sustained improvement that continues after external support is reduced, with standardized processes embedded in routine health system operations.
A distinguishing feature of this opportunity is its emphasis on coordination across all PEPFAR technical areas, rather than treating quality improvement as a siloed activity. The NOFO calls for developing, coordinating, and implementing QI activities across PEPFAR-supported program areas to improve performance and establish standardized approaches that can be maintained over time. By doing so, the activity is expected to help districts supported by PEPFAR South Africa achieve more consistent outcomes in both HIV and TB services and to reduce variation in quality between sites and districts.
In addition to improving services on the ground, the work is intended to generate practical learning for PEPFAR and the broader HIV/TB community about what delivery approaches work best, how to assess service quality effectively, and how to communicate findings in ways that drive action. In other words, the activity is not only about fixing local problems but also about strengthening the broader evidence base on improving program performance at scale in a real-world health system.
Administratively, this funding opportunity was issued by the US Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), Center for Global Health, under Funding Opportunity Number CDC RFA GH19 1921. The mechanism is a cooperative agreement, indicating that CDC anticipates substantial involvement in the supported work. It falls under the health category and CFDA 93.067. The award ceiling is USD 5,000,000, with an expectation of two awards. Eligibility is listed as unrestricted, meaning many entity types may apply, subject to any additional eligibility details in the full announcement. The opportunity was created on August 30, 2018, with an original closing date of October 30, 2018, and applications were due electronically by 11:59 p.m. Eastern Time on the deadline date.Apply for CDC RFA GH19 1921
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Optimizing Performance by Improving Quality (OPIQ) in HIV and HIV/TB Programs in the Republic of South Africa under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
- This funding opportunity was created on Aug 30, 2018.
- Applicants must submit their applications by Oct 30, 2018 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $5,000,000.00 in funding.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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