Opportunity Information: Apply for RFA DK 19 004
The Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs) funding opportunity (RFA DK 19 004) is a National Institutes of Health grant program run by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) within the U.S. Department of Health and Human Services. It uses the P30 center grant mechanism, with clinical trials listed as optional, meaning the program is primarily designed to build and strengthen shared research infrastructure but can support activities that involve clinical trials when appropriate and allowable under the center structure. The overall aim is to support an integrated, coordinated research environment focused on digestive and liver diseases by bringing together teams that span basic science and clinical investigation, so that ideas, methods, and resources flow more easily across disciplines.
At its core, the DDRCC program is about shared resources. Instead of funding many separate labs to each build their own versions of the same specialized tools, the P30 model supports centralized “cores” that multiple investigators can use. These shared cores are intended to increase efficiency and cost-effectiveness while also raising the quality and consistency of research services across a local research community. The program emphasizes productivity and synergy: by giving investigators access to common technical platforms, expertise, and services, a DDRCC should help speed up ongoing projects, reduce duplication, and make it easier to start new collaborations or launch pilot ideas that might not happen without that common infrastructure.
Each proposed center has to be organized around a clear central theme, which should reflect and unify the digestive and/or liver disease research being conducted by the member investigators. That theme is expected to be tightly aligned with NIDDK’s primary mission. An important boundary in the announcement is that the theme should not fall mainly into areas where another NIH Institute or Center is typically the primary funder. In other words, applicants need to make a convincing case that the center’s scientific focus sits squarely within NIDDK’s digestive and liver disease priorities rather than overlapping more strongly with another NIH institute’s core mission.
The announcement is categorized as a discretionary grant in the Health and Food and Nutrition activity area (CFDA 93.847). It anticipates a limited number of awards (expected awards: 5), indicating a competitive, selective process focused on establishing or maintaining a small national network of highly capable core centers. The listed award ceiling is $750,000, which signals that awards are meant to support substantial shared infrastructure and coordinated center activities rather than functioning as large-scale project funding for many independent research studies.
Eligibility is broad and includes a wide range of organizations that can administer NIH grants. Eligible applicants include public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding higher education institutions in those categories), for-profit organizations other than small businesses, small businesses, and multiple levels of government (state, county, city/township, special districts), as well as independent school districts. Tribal governments (federally recognized) and other tribal organizations are eligible, and public housing authorities/Indian housing authorities are also listed. This wide eligibility reflects that the critical requirement is less about organizational type and more about the ability to convene a strong community of investigators and operate high-value shared cores that serve a meaningful digestive/liver disease research theme.
Key timing details in the provided source data show the opportunity was created on March 13, 2019, with an original closing date of July 1, 2021. Those dates are important for historical context and for understanding the specific solicitation cycle, since NIH center programs often recur through reissues or new announcements over time, but applicants would need to confirm the current availability of an active FOA if they are looking to apply now.
In practical terms, a competitive DDRCC application would be expected to describe a coherent, NIDDK-aligned scientific theme; demonstrate an established and active group of basic and clinical investigators who will use the cores; and justify how the proposed shared resources will measurably improve research quality, collaboration, and efficiency. The intended outcome is a center that acts like a hub for digestive and liver disease research at the applicant institution(s), lowering barriers between disciplines, standardizing and expanding access to specialized capabilities, and helping investigators generate stronger, more collaborative science that can lead to new discoveries, better understanding of disease mechanisms, and improved approaches to diagnosis, prevention, and treatment.Apply for RFA DK 19 004
- The Department of Health and Human Services, National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Silvio O. Conte Digestive Diseases Research Core Centers (P30 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on Mar 13, 2019.
- Applicants must submit their applications by Jul 01, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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